A Case-Control Study On The Associations Between Polymorphism Of Angiotensin-converting Enzyme(ACE) Gene And Other Factors And Diabetic Nephropathy In Type 2 Diabetics

Objectives: To explore the associations between insertion/deletion(I/D) polymorphism of Alu sequence at intron 16 of the polymorphism of Angiotensin-converting Enzyme(ACE) gene and other factors and diabetic nephropathy in type 2 diabetic patients.Methods: A hospital-based case control study was conducted in the Metabolic Disease Hospital of Tianjin Medical University from January 2004 to May 2005. 95 DN patients and 126 DM patients without DN were selected as case group and control group respectively. Frequences of age and sex were matched between the two groups. All the information was collected by questionaire in face-to-face interview, which included demographic data, disease history, disease family history, dietetic habit, behavior pattern, social psychologic character, clinical data and laboratory data.