Expressions Of Skp2 And P27～(kip1) In Epithelial Ovarian Tumors And Its Clinical Significance

Objective The purpose of this study was to investigate the correlation between Skp2, P27^kip1 protein expression and the clinicopathological features of epithelial ovarian tumors, and the relationships between the expressions of Skp2 and P27^kip1.Methods Expressions of Skp2, P27^kip1 were examined by immunohistochemistry in 62 epithelial ovarian tumors[12 adenomas, 10 low malignant potential [LMP] tumors, and 40 adenocarcinomas]. No patient received any treatment for cancer before surgery. Resected specimens were fixed in 10% formalin and embedded in paraffin.Results [1] The Skp2 immunoreactivity was localized to the nuclei of ovarianadenocarcinomas cells, Skp2 positive cells were seen frequently and at a intense staining in poorly differentiated carcinoma tissues. The Skp2 labeling frequency in ovarian carcinoma was significantly higher than that in borderline adenomas and ovarian adenomas(P<0.01). The P27^kip1 labeling frequency in ovarian carcinoma was significantly lower than that in ovarian adenomas(P<0.01). [2] The Skp2 protein expression in ovarian carcinoma was positively correlated with clinical stage , histological grade and lymph node metastasis of ovarian adenocarcunomas. The P27^kip1 protein expression in ovarian carcinoma was inversely correlated with clinical stage and histological grades of the tumors (P<0.05). [3] The Skp2 protein expression in ovarian carcinoma was inversely correlated with P27^kip1Conclusion The Skp2 protein expression in ovarian carcinoma increased and was positively correlated with correlated with clinical stage and histological grades of the tumors. Skp2 expression was inversely correlated with P27^kip1. Skp2 expression may play an important role in the development and progression of ovarian adenocarcinomas.