Significance Of Food Allergen In The Etiological Analysis And Treatment Of Henoch-Schonlein Purpura

Objective To investigate the value of vitro food allergen in the confirmation of the etiology of Henoch-Schonlein purpura(HSP) and diet control to assist the HSP treatment. Methods 60 HSP children were studies, and 30 normal children were used as controls. Enzyme immunoassay was applied for the vitro food allergen test 45 HSP children without the test were as controls. Recent treatment outcomes were compared between the groups.Results The positive rate of the total serum IgE in the HSP group was 58.3%, which was higher than that of the normal control group ( 26.7%) , the difference being significant ( x~2=8.038, p < 0.01) . 70.0% of those in the HSP group were allergen positive, while only 40.0% in the control group, the difference being significant ( x~2=7.500, p < 0.01). The percentages of children who were positive to two or more food allergens were 38.3% (23 cases ) and 13.3% respectively in the two groups, the difference being significant ( x~2=4.821, P < 0.05 ) . In the HSP group, the positive rates of different food allergens were: sea foods, 38.3%;vegetables, 36.7%;beans, 13.3%;fruits, 11.7%;meat, egg and milk, 8.3%;flavoring agents, 6.7%. The positive rates of sea foods and vegetables were significantly higher than those in the control group( x~2=4.821, p<0.05;x~2 =4.226, p<0.05), while no significant difference was found in other allergens ( average P > 0.05 ). Diet control was carried out in the 60 HSP children on the basis of the test results. They were followed up for 3 months. The results showed that the recurrence rate was 26.7%, while it was 46.7% for another 45 HSP children without the test which control all animal protein diet and marine products normally, the difference being significant ( x ~2=4.507, p<0.05) .Conclusion Allergen test can help determine the cause of HSP. Sea foods and vegetables are the main factors to induce allergy in this district The specific diet control can control or reduce the recurrence of allergic purpura, which is of great importance in the prevention and treatment of HSP.