Study On The Change And Significance Of HsCRP Before And After Coronary-artery Stenting In The Patients With Coronary Heart Diseas And Hypercholesterolemia

Objectives To investigate the change of plasma level of hypersensitive C-reactive protein (hsCRP) before and after percutaneous coronary intervention (PCI) of patients with coronary heart disease complicated with Hypercholesterolemia;and determine the association between hsCRP and cardiac events.Methods Seventy-six patient with coronary heart disease admitted in Central Hospital of Shengli Oilfield from April, 2004 to January, 2005, who were undergoing a variety of PCIs, were enrolled in our study. Of which, thirty six patients were complicated with Hypercholesterolemia (group A), and forty patients were not (group B). Peripheral blood samples were taken before and 24, 48, 72 hours after PCI to determine the plasma level of hsCRP. The fellow-up of cardiac events was performed to determine the relations between the change of plasma level of hsCRP and cardiac events.Results (1) The serum hsCRP levels increasedsignificantly after PCI compared with that before PCI in both groups. And the change in group A was more significant than that in group B (P<0.01). (2) Duringsix-month follow-up, 16 patients developed cardiac events, of which 11 in group A (30.6%), 5 in group B (12.5%). Patients in group A had more risk for cardiac events than group B (P < 0.0 1). In both groups, the serum concentration of hsCRP before and 24 hrs, 48 hrs, 7 2 hrs after PCI were significantly higher in cardiac event developing patients than that in patients without cardiac events developing. (3) The concentration of plasma cholesterol in both groups was positively associated with the serum hsCRP level before (R value0.85, P <0.01) and 24 hrs (R value0.48, P <0.01), 48 hrs(R value0.43, P <0.01), 72 hrs (R value0.39, P< 0.01) after PCI.Conclusion 1 > The concentration of plasmacholesterol is significant risk factor of cardiac events after PCI .2 > The concentration of plasma cholesterol was positively associated with the serum hsCRP level before after PCI.3, The serum concentration of HSCRP before and after PCI is significant risk factor of cardiac events after PCI.