The Study Of The Numbers Of Circulating Endothelial Progenitor Cells And The Levels Of C-reactive Protein In The Patients With Acute Coronary Syndrome

Objective To investigate the numbers of circulating endothelial progenitor cells (EPCs),the levels of C-reactive protein (C-RP) and the correlation between EPCs and C-RP in the patients with acute coronary syndrome.Methods 39 patients with acute coronary syndrome (ACS), 14 patients with stable angina pectoris(SA) and 16 patients without coronary heart disease (controls),who were diagnosed by their clinical situations, electrocardiogram, cardiac enzyme and coronary angiography. Circulating numbers of EPCs were measured for CD34/CD133 double positive cells by FACS, and the correlations between the levels of CRP and circulating numbers of EPC in each group were also studied. Results The numbers of EPCs in ACS patients were higher than in patients with stable angina pectoris (P<0.001) and the controls (P<0.001). The numbers of EPCs in patients with stable angina pectoris were lower than in the controls (P<0.01). The levels of CRP in patients with ACS were higher than in patients with stable angina pectoris (P=0.005) and the controls (P<0.001). A positive correlation was found between CRP levels and circulating EPCs numbers in ACS, SA and the controls (R=0.775;P<0.005).EPCs inversely correlated with smoking ,hypertention and triglyceride (R=0.42 R=0.63 R=0.307,P=0.024 P=0.016 P=0.012,Respecti-vely) .Conclusions The numbers of EPCs increase highly in patients with ACS and decrease significantly in patients with stable angina pectoris compared to the controls (P <0.001). There is a positive correlation between the numbers of EPCs and thelevels of CRP, and a inverse correlation between the numbers of EPCs and smoking , hypertention and TG.