Expression And Signification Of The Type-1 Inhibitor Of Plasminogen Activator(PAI-1),Transforming Growth Factorβ1(TGF-β1) In Cervical Carcinoma

Objective: to study the expression of the type-1 inhibitor of plasminogen activator (PAI-1), transforming growth factorj31 (TGF-pl) in cervical carcinoma and analyze the influence of cervical carcinoma. Method: PAI-1, TGF-β1 in cervical carcinoma were determined by EnVision immunohistological method and compared between tumor specimens of cervical carcinoma(n=63) and normal cervix tissue (control n=15). Result: 1. The positive frequency of PAI-1 were 0.00% (0/15), 75.00%(6/8), 51.85%(14/27), 82.14%(23/28) in normal group, carcinoma in situs of cervix, high differentiation, middle-low differentiation; the positive frequency of PAI-1 in normal group (0.00%) was lower than in cervical carcinoma (68.25%) significantly (P<0.01); each group was significant (P<0.01), being associated with pathological grading. 2. the positive frequency of TGF-pl were 13.33%(2/15), 25.00% (2/8), 48.15%(13/27), 71.43%(20/28) in normal group, carcinoma in situs of cervix, high differentiation, middle-low differentiation; the positive frequency of TGF-β1 in normal group (13.33%) was lower than in cervical carcinoma (55.56%) significantly (P <0.01); each group was significant (P<0.05), being associated with pathological grading; but the positive frequency of matrix in each group was not significant (P>0.05). 3. expression of TGF-β1 cooperated with...