The Study On Cortical Somatosensory Evoked Potential And Content Of Na～+,K～+,Ca～(2+) In Brains In Septic Rats

Objective: To explore the mechanism of change of cortical somatosensory evoked potential(CSEP) and content of Na⁺, K⁺, Ca²⁺ in brain in septic rats, to know about the protective function of Nimotop. Methods: 150 Wistar rats were randomly devided into control group, sepsis group and Nimotop treated group(n=50 each). The sepsis model was made by cecal ligation and puncture(CLP) in the sepsis group. Nimotop treated group received CLP and Nimoltop by peritoneal injection. Without CLP, the control group got the same treatment. And each group was also divided into 5 groups of 4h, 8h, 12, 16h, 20h after operation(n=10 each). Following indexes were measured in each group: latency of positive(P) wave of CSEP, latency of negative(N) wave of CSEP, P-N peak value of CSEP, content of Na⁺, K⁺, Ca²⁺ and water of brain tissue, mean arterial pressure (MAP) and blood glucose. Result: â‘ At 12, 16, 20h in the sepsis group latencies of P wave and N wave prolonged significantly and P-N peak values also decreased significantly, compared with 4, 8h in the sepsis group (P<0.05). While the tendency of prolonging and decreasing was slower in Nimotop treated group. CSEP did not change until 16h in Nimotop treated group (P<0.05). Compared with 4, 8, 12h in Nimoltop treated group, latencies prolonged and P-N peak values decreased significantly at 16, 20h(P<0.05). Compared with 12, 16, 20h in the sepsis group, latencies shortened and P-N peak values...