Experiment Of Hepatic Inflammatory Pseudoneoplasm And VX2 Carcinoma Perfusion In Rabbits By Contrast-enhanced Ultrasonography

Objective To investigate the clinical value of Contrast enhanced ultrasonography in the differential diagnosis of liver lesions by assessing perfusion of hepatic Inflammatory Pseudoneoplasm and VX2 carcinoma in rabbits by real-time contrast-enhanced ultrasonography and SonoVue.Methods 10 rabbits with IPL and 10 rabbits with VX2 carcinoma was studied by low mechanical index(MI) contrast-enhanced sonography respectively. SonoVue was applied by intravenous bolus injection .Results Real-time contrast-enhanced imaging clearly delineated the dynamic enhancement of the tumors and liver parenchyma during the whole phase. All IPL showed no enhancement in arterial phase , But increased in the portal and delay phase, disappeared slowly in later delay phase ,while the echogenicity of the surrounding liver tissue did. But all VX2 tumors showed hyperechoic enhancement in arterial phase showing three patterns which were homogeneous enhancement, peripheral enhancement and heterogeneous enhancement. Hypoechoic enhancement were observed in the portal and delayed phase compared to the hepatic parenchyma around the tumor lesions. After the arterial phase, the echogenicity of the surrounding liver tissue increased and the intensity of the nodule decreased gradually, Contrast agent was washed out earlier from the tumor than from surrounding liver parenchyma. 1. There was no significant difference of parameters of the time-intensity curve between IPL and the liver parenchyma(P>0.05) .The time to enhancement (ET), the time to peak intensity (PIT) ,the time of ascend (AT) and the time to lighten(LT) of IPL were similar to those of the liver parenchyma. 2. There was significant difference of parameters derived...