The Analysis Of Relevant Factor In Sleep Apnea Syndrome (SAS) Merging Chronic Obstructive Pulmonary Disease (COPD)

Objective The aim of this study is to analyze relevant factor to patients' condition in obstructive sleep apnea-hypopnea syndrome (OSAHS) merging chronic obstructive pulmonary disease (COPD).Method There are 151 patients with suspected OSAHS in sleep breathing disorder department of the first hospital of Shanxi medical university from Jun. 2004 to Dec. 2005. All patients underwent a polysomnography or more during nighttime; and recorded age, body height, body weight and neck circumference (NC); calculated body mass index (BMI=BW/BH²); as well recorded sleeping structure and respiratory parameters. According to the size of apnea -hypopnea index (AHI), all patients were divided into control group (AHI<5), light degree group (5≤AHI≤20), middle group (21≤AHI≤40) and severe group (AHI>40). According to whether with or without COPD, all OSAHS patients were divided into pure OSAHS group and OS group. At same time, age and sex constituent ratio of all patients were calculated. According to NC and BMI, all patients were respectively divided three groups, compared AHI among three groups and analyzed relationship with AHI. The comparison of both NC and BMI among light, middle, severe and control group was completed. The ratio of combination COPD was analyzed among light, middle and severe group. NC, BMI, AHI, sleeping structure and respiratory parameters in pure OSAHS were compared with OS group, including the percentage of the lasting time of SaO₂ inferior to 90% relative to sleeping time (SLT90%), the lowest blood oxygen saturation (LSaO₂), rapid eye movement time (REMT) , non-rapid eye movement time (NREMT) . The Kruskal Wallis Test and Spearman regression analysis were completed using SPSS 11.5.Results In age constituent ratio, 40～50 years old group was higher prevalent than others, and the second was 50～60 years old group, but both <20 years old group and >70 years old group were less. The sex constituent ratio in male is higher than those in female. The constituent ratio in adult female was significant difference from those in postmenopausal female (P<0.05). According to the size of NC, all patients were divided into three groups, <40cm group, from 40 to 43 cm group and >43cm group. The difference among three groups had statistical significance (P<0.05). According to the size of BMI, all patients were divided into three groups, <24 kg/m² group, from 24 to 28 kg/m² group and >28 kg/m² group. The difference among three groups had statistical significance (P<0.05). The positive correlation between NC and BMI was found in the patient with OSAHS, and the positive correlation between them and AHI was also found. NC...