Studies On The Properties Of Oil-in-water Microemulsions And Solubilization Of M-Nisoldipine In Tween80-based Microemulsion System

Microemulsions are transparent, thermodynamically stable, low-viscosity, isotropic mixtures of oil, water and surfactant, frenquently in combination with a co- surfactant. These systems are currently of interest to the pharmaceutical scientists because they have a potential to act as delivery vehicles and can be used by many dosage forms, such as oral, injection, transdermal and ocular delivery. This paper studied on the microemulsion systems stabled by Tween80 and compared the solubility of m-nisoldipine in the O/W microemulsion systems to that in the micellar solution.Objective: to study the factors affecting the formulation and stability of the microemulsion stabled by Tween80 and to investigate the solubilization of m-nisoldipine in the O/W microemulsion systems.Methods: the influence of different sorts of co-surfactants on the surface tension of Tween80 was studied by the surface tension isotherm of Tween80 and Tween80/co-surfactants solutions. According to the pseudo-ternary phase diagrams, we researched on the effect of elements in the formation of microemusion, including the sorts of co-surfactants and the oils,...