Effects Of Rats' Prenatal Exposure To Low Level Lead On Offspring's Learning, Memory And The Expression Of Neural Cell Adhesion Molecule In Hippocampus In Their Brains

Objectives:Lead is a kind of toxic heavy metal in industry and contributes to the damages of functions of many systems especially nervous system. Children are very susceptible to the toxicity of lead because of their physiological characteristic. Besides environmental pollution, the prenatal exposure to lead is a main approach to damage on children. Because Lead can transport from mother to fetus through placenta easily, the contents of lead in cord blood is correlated with that in maternal blood closely. It is approved that prenatal exposure to low level lead would lead to abortion, premature delivery, fetal death, abnormality and imbecile. Lead can come into the nervous system of fetus easily through the incomplete blood-brain barrier and do harm to the brain. As a result, the offspring's ability of learning and memory would be affected. So, it is a significant task for every country to study the genetoxic mechanism in nervous system of lead.Neural Cell Adhesion Molecule (NCAM) is a kind of active molecule in nervous system. It is distributed widely in the growing brain. NCAM plays a key role in the interior action of...