Changes Of CD8～+T Cells Subset And Expression Of Costimulatory Molecules CD28 And CD137 In Peripheral Blood T Cells In Patients With Laryngeal Squamous Carcinoma

Objective: To investigate the changes of CD8+T cells subset and expression of the costimulatory molecules CD28 and CD137 in peripheral blood T cells in patients with laryngeal squamous carcinoma. Accordingly define the state of cell-mediated immunity of patients with laryngeal carcinoma and function of costimulatory molecules CD28 and CD137 in the process of occurrence and development of laryngeal carcinoma and its roles in anti-tumor actual immunity.Methods1. Target: 30 patients with laryngeal carcinoma and 15 healthy persons were enrolled in this study. All the patients accepted operations and pathological confirmation in the department of otolaryngology of bethune international peace hospital from Feb 2005 to Jan 2006. It was excluded who had liverish or nephritic disease, immunological disease, cardiac or cerebrovascular disease, infective disease and so on. No patients accepted actinotheraphy and chemotherapeutics before. Clinical original information of every patient was recorded in detail.2. Group: According to the standard of clinical stage of...