Levels Of Matrix Metalloproteinases In Serum And Cerebrospinal-fluid In Children With Central Nervous System Infection And Impairment Of Blood-brain Barrier

Objective: Central nervous system (CNS) infection is a severe disease to endanger the children's life because of its high morbidity, mortality and disability rate. The pathogenesis and pathophysiology of the CNS infection are very complicated. The impairment of blood-brain barrier (BBB) plays an important role in the CNS infection, and is a focus of medical research. The present study aimed to explore the contribution of matrix metalloproteinases (MMPs) in the impairment of BBB in the CNS infection, through measuring the levels of MMPs (MMP-2 and MMP-9) in serum and cerebrospinal-fluid (CSF) in children with purulent meningitis (PM), viral encephalitis (VE) and control. It is also try to evaluate the utility of MMPs (MMP-2 and MMP-9) in early diagnosis, state of an illness, and prognosis in CNS infection.Methods1 Experiment group: The group of PM consisted of 18 children with age from 6 months to 13 years in which 11 male and 7 female.The group of VE consisted of 22 children with age from 6 months to 14 years in which 10 male and 12 female. The...