Analysis Of Current Situation Of Central Nervous System Infectious Diseases In The Second Hospital Of Hebei Medical University

Objective: Central nervous system infections refer to those acute orchronic inflammatory diseases that brain parenchyma, spinal cord, theirmembrane and blood vessels are invaded by pathogenic micro-organisms,which include bacteria, fungi, viruses, spirochetes, parasites, rickettsia, prionprotein et al. It is one of the common diseases of the central nervoussystem(CNS).There are millions of CNS infectious cases per year in China. Ithas high case mortality rate (CMR) and can cause severe neurologicalsequelae. It is also seriously threatening human health. Viral encephalitis(meningitis)(VE/M), purulent meningitis (PM), tuberculous meningitis(TBM), cryptococcal meningitis (CM) and cerebral cysticercosis (CC) arecommon clinical types. Based on this situation, the research on the distributionof CNS infections prevalence has increased steadily. But more of themconcentrated in a particular pathogen and lack of comprehensive sum-up aboutthe epidemiological distribution. Besides, the article of CNS infections aboutShijiazhuang area is even more scarce.This study was undertaken to learn more about the progressing trend,distribution and pathogen spectrum of common central nervous systeminfectious diseases in Shijiazhuang and it’s surrounding areas by analyzing theclinical data of9067cases with CNS infections. And then to summarize theclinical characteristics, progressing trend and distribution of the diseases. Soas to enrich the database of infectious diseases in China, give directions to theresearch for CNS infections and give guidance to the prevention work.Method：We collected the clinical data of9067cases who were treated inthe second hospital of Hebei Medical University from1996to2011, andselected fit cases to make them five groups which consisted of group VE/M, group PM, group TBM, group CM and group CC. We collected informationlike admission date, discharge date, patient’s name, gender, age, principaldiagnosis, principal diagnosis outcome, other diagnosis, other diagnosisoutcome, patient occupation, home address and so on. We will give acomprehensive analysis of the pathogen distribution, the annual distribution,seasonal distribution, admission day, age distribution, gender distribution,rural-urban distribution occupation distribution and other aspects.Results：During16years, there are9067patients of CNS infectiousdiseases admitted in our hospital. The numbers of inpatients with VE/M, PM,TBM, CM and CC are6719,580,816,83,869respectively, and theproportions are74.10%,6.4%,9.00%,0.92%,9.58%separately. Thehospitalization numbers of VE/M, PM, TBM, CM and CC in the2004-2011period are219.68%,63.64%,46.53%and318.75%higher than that of the1996-2003period. VE/M are prone to occur in Jul, Aug and Sep. While theperiod of TBM concentrate in Apr to Jun. VE/M and PM occurre morefrequently in children under10. TBM are more common in young people aged20-29. CC sees more at teenager aged10-19. The gender differences of PMand CC were significant, and they were respectively1.90:1and1.66:1. CNSinfectious diseases are mainly located in the countryside. The rural cases ofPM account for87.93%, which makes it the most evident in rural-urbandifference. The occupation of patients with VE/M is mainly on student. Whilethe PM sees more in children, and TBM, CM, CC are more common infarmers.Conclusion： In the recent years, the patients of CNS infectiousdiseases in Shijiazhuang City, Hebei Province and its surrounding areas takeon a significant increasing trend. It is essential for clinicians to address thepathogenesis, diagnosis and treatment of CNS infectious diseases within-depth studies. Meanwhile we also looking forward to drawing therelevant departments’ attention to develop more scientific prevention strategies,and provide guidance for the control work.