Observing The Effects Of Uterus, Ovary And Breast In Postmenopausal Women Under Long-term And Low-Dose Hormone Replacement Therapy By Ultrasonography

Objective To investigate the effects of uterus, ovary and breast in postmenopausal women under long-term and low-dose hormone replacement therapy (HRT) by using ultrasonography.Methods Total of 52 healthy postmenopausal women was divided into two study groups according to different schedule in medicine. One study group was used low-does of Livial (generic:Tibolone); another group was given low-does of estrogen plus progestin(E-P). Duration of all subjects was from 5 to 31 years. The appearance and structural features of uterus, ovary and breast were observed by transvaginal ultrasonography and mammary ultrasonography.Results When compared with the non-HRT women, the uterine volume, endometrial thickness, bilateral ovarian area, bilateral breast glandular section thickness and breast duct width after HRT were higher than control group, but significant difference in endometrial thickness was found (p<0.05). The uterine volume and breast glandular section thickness in the women with estrogen and progestin were significantly different from those with non-HRT (p<0.05). No variation was observed in the two treatment groups. The breast structure changes occurrence of the subjects with HRT was higher than that of non-HRT except the type of local focus fibrosis. The incidence of lobule hyperplasic type in either treatment groups was higher than control group (the group with Livial :P<0.05, the group with E-P:...