The Neural Mechanism Underlying Urinary Bladder Disfunction Secondary To Chronic Prostatitis

Background and objectives Chronic prostatitis(CP) occupies a big portion of urological clinic workload. The pathophysiology of CP is still elusive due to a myriad of etiologies and complex pathology as well as symptoms. The therapeutic outcome of CP is unfortunately very disappointing using available regimens and the patients suffer tremendously from this disease. Pain, voiding dysfunction and sexual dysfunction are three main manifestations of CP. However, with respect to voiding dysfunction, little is known and great controversy exists. Many investigations ascribed the voiding dysfunction to the functional obstruction at posterior urethra but in some patients, without functional urethral obstruction, symptoms and abnormal urodynamic findings were still present. Thus, further study needed to reveal the responsible mechanism.Now, many scholars had found there were some neural reflex existing mutual viscera organs and between viscera organs and some part in the body. A viscera organ or some part of the body stimulation could affect other organs's function related to it. There were reports of this neural reflex on urinary bladder, too. The abnormal bladder functions was frequent reason of the voiding dysfunction, and can voiding dysfunction associated with CP be caused by a possible neural reflex between the prostate and urinary bladder? To our best knowledge, there are no report concerning this so the interesting hypothesis is worthy of being tested. This study will confirm the neural mechanism of abnormal micturition and suggest a potential therapy for voiding dysfunction of CP through neuromodulational.Methods The neural reflex between the prostate and urinary bladder was studied by physiological, neuroanatomical and functional approaches in male adult Wistar rats, and then the neural mechanism of the urinary bladder disfunction induced by CP was proposed.1. The functional changes of urinary bladder induced nocuous stimulus to the prostate were studied by filling cystometry performed two minutes after 5% formalin injected into the prostate. The formalin was replaced by 0.9% saline in control group.2. The bladder myoelectrical activities were simultaneously recorded when the prostate was electrically stimulated. The role of the brain and spinal cord in the neural...