The Clinical Exploratory Study Of United QST And SSR Early Diagnosing DPN

Background: Diabetic peripheral neuropathy(DPN) is a kind of important and common chronic complication of diabetes mellitus, which may impair motor fibers ,sensory fibers and automatic fibers of the peripheral nerves. If according to clinical manifestation or nerve conductive study(NCV),DM patients'impairment of peripheral nerves covers about 47%~91%.DPN often occurs tardily, and DM patients usually have no subjective symptoms. Once clinical symptoms are felt, nonreversible pathological changes of peripheral nerves have occurred. At this time, the therapeutic efficacy and the quality of life of the patients are seriously influenced than the ones of the patients without subjective symptoms; but at the early period of DPN, the pathological changes is reversible. If positively treated, the patient without symptoms may revive to the normal. We can know that early discovery of DPN has important medical and social significance. Since nerve electrophysiological tests ,such as NCV, appear and were widely applied, early diagnosing rate of DPN is seriously elevated owing to having objective results; NCV reflects the conductive function of big myelinated never fiber(Aαand Aβ) ,but the studies of pathology and clinic indicate that in the early period of DPN small non-myelinated nerve fibers(Aδ) and automatic nerve C fibers(small fibers)are mostly impaired, so appliance of classical NCV is limited at this time. To early discover the peripheral never impairment of DM patients, Widely studies are done about small fiber. Many literatures report that quantitative sensory testing(QST) and sympathetic skin response(SSR) are two kind of good methods of detect function of small never fibers, they may be applied to early discover DPN.QST can detect...