Early Diagnosis Of Diabetic Peripheral Neuropathy (DPN) And Clinical Study On Jinmaitong Composita On DPN

Part OneEarly diagnosis of diabetic peripheral neuropathy (DPN) and clinical study on the measure of its TCM syndrome differentiationBackground and Objectives:It is well known that the early diagnosis and treatment of diabetic peripheral neuropathy (DPN) is beneficial for a better prognosis for its high morbility, which is greater than 90%, and it is important to identify subclinical some neuropathy before the clinical findings appear. But there was a limitation for the classic nerve conduction velocity detecting to measure the function of small nerve fibers and/or the autonomic nerve fibers, for it could only evaluate the function of some fast-conduction nerve fiber, which is only a little portion of the whole nerve fibers, and could not reflect the velocity spectrum of the whole nerve fibers. So it is in need to study and establish some methods to diagnose DPN early and to determine the velocity of slow-conduction nerve fibers. The technique of sympatheitc skin response (SSR) is an electrophysical testing to assess the small automatic nerve fibers function at early stage of disease, and has been thought as an effective measure to to find the abnormality of samll fibers. In addition, based on the principle of conduction collision of nerve impulse, the computer-assisted collision technique (CCT) is a new technique for analyzing motor nerve conduction velocity distribution (CVD), which can reflect the conductive characteristic of the whole nerve fibers. Up to date, few domestic studies about CVD and /or the SSR comparing with the classic NCV have been reported. So the objective of this study is to establish new methods to help diagnose diabetic peripheral neuropathy at its very early stage.In resent years, great progress has been achieved for Traditional Chinese Medicine in...