Expression And Significance Of Survivin And PCNA In The Process Of Oral Squamous Cell Carcinoma

BackgroundSquamous cell carcinoma of oral (OSCC) is the most common malignant tumour in the oral cavity, accounting for more than 80% of the oral malignant tumour.However,study the process of OSCC,making early correct diagnoses on OSCC have important directive signifcance to clinical work.Survivin is a new antiapoptosis gene, which is discovered recently, and survivin protein is a new member of inhibition of apoptosis protein(IAP) family. It can inhibit cell apoptosis, and play a significant role in cell mitosis and cytoplastic cleavage. Studys suggest that survivin is a tumor specific apoptosis gene, it is expressed during the fetal development and in common human tumors, but cannot be found in normal adult tissues. Proliferating cell nuclear antigen(PCNA) is a assistant factor of DNA polymerase 8, participating in DNA synthesize, and playing a great role in regulation of cell cycle. The cyclic change of PCNA is related to cell proliferating process, it's a milestone during the period of cell proliferation and malignant disease.ObjectiveThe aim is to investigate the function of survivin in oral squamous cell carcinoma of oral (OSCC) and evolution, and its relation to cell proliferation. Through the study of survivin expression in OSCC and its relation to cell proliferating activity, we analyzed the molecular mechanism of survivin during oncogenesis. It may be a valuable target for early diagnosis and therapy of OSCC,and can provide a new target gene for effectual remedy to OSCC.