1.Expression Of Osteopontin Protein In Transitional Cell Carcinomas Of The Bladder And Its Clinical Significance 2.The Affections Of HCPT And THP Intravesical Instillation On Immunological Reactivity Of Patients With Transitional Cell Carcinoma Of The Bla

Bladder carcinoma is one of commonly seen solid tumors, which badly endangers the people's health and life. In clinical practice, to predictor the prognosis of patients with bladder cancer is mainly depend on TNM and grading systems, although there are many markers of bladder cancer, such as BTA, NMP22, FDP, Telomerase, Microsatellite and so on. The sensitivities and specialities of these markers are limit. So a need for tumor marker that can be incorporated into clinical practice to add prognostic information and to refine the conventional TNM and grading systems in terms of treatment response and prognosis is crucial.Osteopontin (OPN) was initially isolated from bovine bone cortex, as a complex syalilated phospho-glyco-protein of around 60 kDa in 1986, It has been long considered a structural bone protein linking bone cells to the bone extracellular matrix. Many studies shown OPN is expressed and secreted by numerous human cancers. OPN functions in cell adhesion, chemotaxis, macrophage-directed interleukin-10 (IL-10) suppression, stress-dependent angiogenesis, prevention of apoptosis, and anchorage-independent growth of tumor cells by regulating cell-matrix interactions and cellular signaling through binding with integrin and CD44 receptors. While constitutive expression of OPN exists in several cell types, induced expression has been detected in T-lymphocytes, epidermal cells, bone cells, macrophages, and tumor cells in remodeling processes such as inflammation, ischemia-reperfusion, bone resorption, and tumor progression. Recently, substantial evidence has linked OPN with the regulation of metastatic spread by tumor cells. However, the molecular mechanisms that define the role of OPN in tumor metastasis are incompletely understood, growing evidence supports a role for OPN as a potential prognostic factor for various human cancers. In order to elucidate the relationship between expression of osteopontin and bladder cancer, we conducted reseachs as follow; Objective: To investigate the expression of Osteopontin (OPN) in transitional cell carcinomas of the bladder and the significance of OPN in tumorigenesis and prognosis.