Oxidative Stress Injury Caused By Hydrogen Peroxide On Cultured Endothelial Progenitor Cells Derived From Pig Bone Marrow

Background and aimEndothelial progenitor cells(EPCs) as a kind of precursor cell possess the ability to proliferate and differentiate into mature endothelial cells(ECs). In adult, EPCs in the peripheral circulation derive from bone marrow(BM). They recruit and home at ischemic tissue to improve the function of ischemic organs through vasculogenesis and angiogenesis. Therefore EPCs has great potential for clinical application.Recent studies showed that peripheral EPCs in CAD patients reduced nearly one half in number and were dysfunctional in migration, which might contribute to insufficient neovascularization in patients with CAD. Although the mechanisms of the reduction in the number of EPCs and their functional impairment remain to be determined, it has been pointed that the reduction and dysfunction of EPCs is in an inverse linear relationship with the number of atherosclerotic risk factors include hyperlipoidemia, hypertension, diabetes, smoking et al. Because oxidative stress is one common way to initiate artherosclerosis among these risk factors, it presumely contribute to the reduction and functional impairment of EPCs in patients with...