The Establishment Of The Sustained Release System Of SP-PLGA Nanoparticles And The Preliminary Study Of Their Biological Effects

Periodontal tissue regenerating in tooth movement has been regulated by nerve system.It has benn confirmed that SP and CGRP play an important role in periodontal tissues remodeling . As peptoid substance, neuronpeptides are easily degraded by enzymes and their half life periods are only several minutes. This make it impossible for them to generate biological effect for a long time. In order to study and examine their effects for a longer time,it is necessary to establish a sustained release system.The aim of this study was to establish a sustained substance P release system and make it release substance P continuously and slowly so that the effect time of substance P was extended. We apply the sustained release system to celluar and animal experiments so as to study the effect of substance P on PDLC and the remodeling of alveolar bone. The following are the main contents and results of this study:...