Expression And Significance Of VEGF-C,VEGFR-3 In Mammary Neoplasm

Objective Breast cancer is a kind of maligant tumor which affects on women's health all over the world. The disease incidence of breast cancer has a trend of increasing. In some areas,especially in some cities,it has leaped to first place in the maligant tumors of females.Breast has plentiful lymphatic vessel network,thus metastasis of early-stage breast cancer occurs primarily through the lymphatic system. It has been proved wether or not lymphatic metastasis of breast cancer is a major factor to the clinical prognosis.Therefore,in the process of diagnosis and therapy of breast cancer,how to check and control lymphatic metastasis is very important.VEGF-C(vascurlar endothelial growth factor-C)is one member of the VEGF family.It is a specific regulating factor for lymphatic endothelial cells and attend the lymphangiogenesis during embryonic development.VEGFR-3 is primarily expressed on lymphatic endothelium.Some researches have found that VEGF-C can bind to VEGFR-3 and accelerates the process of lymph vessel hyperplasia and enlargement,induces the tumor lymphangiogenesis and is highly correlated with lymphatic metastasis.In foreign literature about the correlation between lymphatic metastasis of breast cancer and VEGF-C have been reported,but the expression of VEGF-C,VEGFR-3 in breast neoplasms and its relationship with lymphatic metastasis of breast cancer and clinicopathological...