Study On The Correlation Between Spiral CT Features And Expression Of VEGF-C,VEGFR-3 And Lymphatic Vessel Density In Gastric Cancer

Background & Purpose: Gastric cancer is one of the most common malignant tumors of gastrointestinal tract, its mortality is very high. It has been always in progression before it was detected. Its invasion and metastasis are the leading cause of death. Investigating the relationship between outwards appearance and molecular mechanism of the invasion and metastasis in gastric cancer, therefore, is significant topic to radiology, pathology and molecular biology. Spiral CT (SCT) can provide sufficient and accurate information on the characteristics of gastric cancer. So it is considered to be a practical and credible method to diagnose gastric cancer. Vascular endothelial growth factor C (VEGF-C) is a member of vascular endothelial growth factor family. Recent researches reveal that VEGF-C can promote the lymphangiogenesis in tumor and is over-expression in many malignant tumors. It may induce the proliferation of lymphatic vessel endothelial cell and subsequent lymphangiogenesis in tumor by combining with its receptor: vascular endothelial growth factor receptor 3(VEGFR-3), which is expressed in the lymphatic endothelial cells of the adult. VEGF-C and VEGFR-3 have a co-effect. Their over-expression played an important role in the invasion and metastasis of tumor, especially in lymphatic metastasis. In general, imaging features of gastric cancer is determined by the pathologic alteration, while the latter is determined by its biologic characteristic. The purpose this study is to investigate the relationship between the SCT features and...