Expressions Of TS, TP And PCNA In Bladder Cancer Tissue And Their Clinical Significances

Background and Objective: Bladder tumor is the first common tumor in urology in our country.The incidence rates of bladder carcinoma are ranked the eighth among human's tumor.Bladder transitional cell carcinoma occupy over 90% in bladder cancer ,the rest are squamous cell carcinoma and adenocarcinoma etc.Bladder cancer greatly affect the health of human being.With the progress of diagnotic methods,the incidence rates of bladder cancer are increasing.Nowdays the treatment methods for bladder carcinoma are mainly concentrated on operation , radiotherapy, chemotherapy and immunotherapy which although have got some success, but some patients didn't get control or relapsed after primary treatment due to the inefficiency of regional healing. Therefore, it is an important subject to search new method that can effectively detect and cure bladder carcinoma or block its metastasis and relapse.Thymidylate synthase (TS) and thymidine phosphorylase (TP) are two key enzymes involved in pyrimidine metabolism and DNA synthesis. Thymidylate synthase (TS) catalyzes the reductive methylation of dUMP to generate thymidylate, which was the key step for de novo DNA biosynthesis. The high expression of TS was associated with abnormal cell proliferating, apoptosis regression and resisting to chematherapy. Thymidine phosphorylase (TP) catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogs to their respective bases and 2-deoxyribose-1-phosphate. It also catalyzes deoxyribosyl transfer from one deoxynucleoside to another base to form a second nucleoside. It is identical with...