The Experimental Study Of Repairing Rabbit Femoral Condyles Defect By SIS/HA-TCP Composites With Different Ratio.

Background:The bone defects have been the one of most trouble in clinical therapeutics. It can always result in severe functional disorder and deformity. Although bone allografts are commonly used to reconstruct the defects, but significant problems such as donor site morbidity and the limited supply associated with autogenous bone harvesting remain. To overcome these problems, various osteoconductive biomaterials including inorganic materials, synthetic porous polymers, have been considered as bone graft substitutes. Recently, attempts have been made to integrate the advantages exhibited by each of these two kinds of materials, ceramic and collagen composites in particular, to make a new material with desirable properties.Small intestinal submucosa (SIS), a nature collagen tissue from porcine jejunum, is one of significant nature bioactive materials. The SIS material consists of naturally occurring ECM that has been shown to be rich in components which support angiogenesis such as fibronectin, glycosaminoglycans including heparin, several collagens including Types I, III, IV, V and VI, and angiogenic growth factors such as basic FGF (bFGF) and VEGF. In addition, an acellular resorbable scaffold derived from SIS has been shown to be rapidly resorbed and posses characteristics that make it a suitable material for tissue engineering applications at varied sites, including musculoskeletal structures, skins, body wall, dura mater, urinary bladder and blood vessels. However, there is little research about the SIS and ceramic composites as bone reconstruction.Objectives:According to the experiences of previous studies about ceramic and collagen composites, we use SIS and HA-TCP to generate a new composites for repairing rabbit femoral condyles bone defects and study the optimal ratio of SIS/HA-TCP composites with different ratio.