Polymorphisms Of Metabolic Enzyme Genes, Living Habits And Prostate Cancer Susceptibility: A Case-control Study In Population Of Han Nationality In Southern China

Objective To investigate the association among genetic polymorphisms of phase I and II metabolic enzyme (CYP2E1,CYP17,GSTM1 and GSTTl) genes, living habits and the risk of prostate cancer (PCa) in population of Han nationality in Southern China.Methods A case-control study including 163 PCa patients and 202 age-matched controls was conducted. The genotypic polymorphisms of CYP2E1, CYP17, GSTM1 and GSTTl gene were analyzed by PCR-RFLP assay using genomic DNA isolated from peripheral blood lymphocytes of the subjects.Results The history of long-term toxicant exposure (OR=2.27, 95%CI: 1.26-4.09), the tumor history of lineal consanguinity (OR=2.19,...