Experimental Study Of The Effect Of Mycophenolate Mofetil On Inflammatory Mechanism In Diabetic Nephropathy

Background and objective: Diabetic nephropathy is the principal cause of end-stage renal failure in developing countries, with renal disease as a major cause of morbidity and mortality in the diabetic population. An interaction of metabolic and hemodynamic factors has been considered a traditional aspect involved in the development of renal lesions in patients with type 1 or type 2 diabetes. However, the recent study in vivo and in vitro evidence demonstrated inflammation have become an important cause in chronic progressive renal disease in diabetic state. As macrophages infiltration being major mark, inflammatory mediators release and interaction being experimental direction , and immunosuppressive agent to block inflammatory mechanism influence being observe effect in the progress of finding new therapeutic methods in diabetic kidneys are increasingly becoming study spot . Mycophenolate mofetil , as an immunosuppressive agent ,inially used to resist immunological rejection in patients after renal transplantation, recently found has treatment effects in noninflammatory renal diseases,including diabetic nephropathy, which can prevent albuminuria, glomerular macrophage infiltration and glomerulosclerosis,but has no effect on blood pressure, glomerular dynamics or blood glucose levels. The present study aimed at evaluating the effect of mycophenolate mofetil on inflammatory mediators release and probing proper its mechanism in kidney in diabetic rat induced by STZ.Methods: Thirty adult male Sprague-Dawley rats were randomly separated into three groups: control group (n=10), model group (n=10), model group treated with MMF (MMF group, n=10) .To induce an experimental model of diabetes, rats received a single intraperitoneal injection of STZ (65mg·kg ) after uninephrectomy. MMF group received MMF 10mg·kg ·d by gavage. 8 weeks after STZ...