Changes Of UPA And TGF-β1 In Placenta And Plasma In Patients With Preeclampsia

Objective To study the roles of uPA and TGF-β1 on the etiology of preeclampsia(PE).Methods The levels of uPA and TGF-β1 were determined in 30 patients with PE. The data were compared with those of normal pregnant group(n=12).The levels of uPA and TGF-β1 in placenta tissue extraction and plasma were measured by means of enzyme linked immunosorbent assay(ELISA).Results (1)The level of uPA in placenta in PE group (11.42±4.67) ng/g was lower than that in normal pregnant group[ (32.62±2.85) ng/g, P <0.001]. The level of uPA in severe PE group (8.11±4.25) ng/g was lower than that in mild PE group[ (15.83±3.07) ng/g, P <0.001]. The level of TGF-β1 in placenta in PE group (1.12±0.37) ng/g was higher than that in normal pregnant group[ (0.83±0.21) ng/g, P <0.05]. The was no significantly statistical difference in the levels of TGF-β1 between the severe PE group (1.33±0.35) ng/g and the mild PE group[ (0.91±0.41) ng/g, P >0.05]. (2)The level of uPA in plasma in PE group (466.61±34.68) pg/ml was lower than that in normal pregnant group[ (649.47±41.12) pg/ml, P <0.01]. There was no significantly statistical difference in the levels of uPA between the severe PE group (440.01±42.95) pg/ml and the mild PE group[ (486.56±28.90) pg/ml, P >0.05]. The level of TGF-β1 in plasma in PE group (13.30±4.57) ng/ml was higher than that in normal pregnant group[ (9.617±4.19) ng/ml, P <0.05]. The was no significantly statistical difference in the levels of TGF-β1 between the severe PE...