The Clinical Investigation Of The Protective Effect Of Tangshenning On Kidney Function Of The Early Diabetic Nephropathy Patients

Background and Object: Diabetic nephropathy(DN) is one of the most usual and severest microvascular complications,also is major reason of death who suffered from diabetes.During the early stage of diabetic nephropathy,high glomerular filteration rate and megaglomerulus are found. In the late stage,proliferative extracellular matrix in the aera of glomerular mesangium and fibrosis of tubular interstial come into being. Both lead to glomerulosclerosis. The clinic characteristics of diabetic nephropathy are microalbulin,hypertension,edema and even renal failure.Mechanisms for the development and progression of diabetic nephropathy is not known completely and is still lack of systemic,active precaution.Diabetic nephropathy has become the main reason of death for those diabetic patients. Now,some measurements are applied to treat diabetes,such as reduction of protein intake and animal-derived protein,control of blood glucose,blood pressure, modulation of dyslipid and abnormality of blood rheology, improvement of microcirculation and applyment of angiotension converting enzymes inhibitors or angiotension II receptor blockers.And effect of inhibitors of AGEs,PGE₁ on ET-1 is not sound.Because mechanism of DN is not clear,phiscians haven't a effective way to treat the disease and long term therapeutic result is not satisfied. At the same time some side-effects of...