The Study Of Preparation And Assessment In Vitro Of The Gastric Floating Sustained-Release Capsule Of Tripterygium Wilfordii Hook.F. And Determination Of Triptolide

Background and objective: Tripterygium Wilfordii Hook. f. which belongs to the Celastraceae Tripterygium plant, its extraction acetylacetic ester was used in clinic preparation, the primary component is epoxy terpenoid lactone. Tripterygium Wilfordii Hook. f. is a herbal medicine which has many functions such as heat-clearing and resolving the exterior,coursing wind and opening venation,stimulating the circulation of the blood and causing the muscles and jointing to relax, dehygrosis , eliminating edema and alleviating pain. At present the extraction acetylacetic ester has been widely used in some immune disorder diseases such as rheumatoid arthritis(RA), the total efficiency reached approximately 89%. Whereas there have found many side effects in the 30 years'application. So how to select different preparations to decrease the side effects is a imperative clinic problem needed to be resolved.Gastric floating sustained-release preparation is made by hydromechanical balanceable theory, after taking it orally, it can float on...