Study On The Treatment Of Acute Tubular Necrosis By Transplantation Of Autologous Bone Marrow-derived Adult Stem Cells

Objectives:This research is to establish the model of acute tubular necrosis through renal ischemic-reperfusion (I/R) injury in the rabbits. The impact on renal function by transplantation of autologous bone marrow mononuclear cells (BMMNCs) into the kidney through renal artery is observed. Whether the transplanted bone marrow-derived stem cells have the ability of homing to the injured renal tissue and the distribution of the stem cells in the kidney are also observed. Whether the possible mechanism of the transplanted autologous bone marrow-derived stem cells can accelerate the repair of the acute tubular necrosis and the efficient pathway of the stem cells transplantation are discussed, so as to provide experimental basis for transplanting bone marrow-derived stem cells to treat acute tubular necrosis.Methods:1. Division of groups: Japanese white rabbits (n=42) were divided randomly into two groups, including a control group (I/R +0.9%NaCl solutions infusion group) and a transplantation group (I/R + BMMNCs infusion group). Each group had 21 rabbits.