The Study On The Effect Of Urotensin Ⅱ On Apoptosis In Human Umbilical Vein Endothelial Cells And Its Possible Mechanism

Background:Cardiovascular diseases is one of the most dangerous diseases which damages peoples heath in these days. In recent years, more and more attentions have been paid to cardiovascular active factors such as ET-1, AngII, ADM, et al. These factors play a very important way in the pathologic physiologic process of cardiovascular diseases. Therefore there is necessity to find out the role of every factor in cardiovascular diseases and there relations between each other. Urotensin II (UII) is a peptide that was originally isolated and characterized in fish. It is verified that UII has a wide distribution in nervous system of both mollusc and mammals. Ames et al found that UII and its special receptor, an isolate G-protein coupled receptor 14, which is homologous with the rat's GPR14, have a wide distribution in cardiovascular system . Binding its receptor, urotensin can elicit the increase of [Ca²⁺] in cell, and participate in a series of cardiovascular response such as vascular contraction and cardiac muscle inhibition. Urotensin-II, the most potent mammalian vasoconstrictor identified, whose effect is nearly twenty times stronger than ET-1 can stimulate the proliferation of vessel smooth muscle cells and cardiac fibroblasts. Terefore, UII...