The Studies Of Ibuprofen Sustained Release Pellets

Ibuprofen(Ib) is a 2-arylpropionic acid marketed as a non-steroidal antiinflamatory drug (NSAID) and is readily available in many dosage forms. Ibuprofen has been widely used clinically to treat rheumatoid arthritis, post-operative pains, pains associated with common colds, etc. The purpose of the present study was designed to develop a kind of ibuprofen sustained release pellets capsules which would decrease adverse effects and improve its bioavailability, and which would be more convenient for patients to use.HPLC method was utilized to determine the ibuprofen content in pellets, HPLC method was developed for assaying release of ibuprofen sustained release capsules. The HPLC ultraviolet method was established to monitor the plasma concentration in dogs.The preformulation results showed that ibuprofen is a poorly water-soluble drug. With the buffer pH increased, the ibuprofen dissolution increased in various buffer pH fluids. The octanol/water partition coefficient variation is obvious. It shows that the drug absorption is influenced in various physiological pH fluids.Ibuprofen pellets were prepared by means of powder accumulation with the centrifugal granulation technology. Through the formulation filtration and process observation, it was discovered that the yield of the objective pellets(20/24 mesh cut) was above 50% and the average ibuprofen content was 40%. The results suggested the centrifugal granulation technology for ibuprofen may not reach the expected goals.Ibuprofen pellets were prepared by means of extrusion-spheronization. Investigation...