Study On Preparation Of Potassium Citrate Sustained-release Pellets

Potassium citrate is widely used in clinical prevention and treatment of urinary stones first-line drugs. Potassium citrate can alkaline urine, reducing the formation of salt crystals in urine, increase urinary excretion of citrate, which inhibits the formation of uric acid stones and urinary system stones. Ordinary and oral granules on the domestic market. There are sustained release tablets of sustained release formulation. Potassium Citrate Sustained Release Tablets Urocit?-k wax produced by foreign pharmaceutical companies MISSION.In the Chinese market, potassium citrate sustained release tablets only with Livzon Dele and Jieshitong. The study will be made potassium citrate sustained-release pellets for improving patient compliance and reduce adverse reactions.UV spectrophotometric determination was developer for assaying contend and drug release of Potassium citrate. Citrate ions and copper ion can occur complexation reactions.And the complex has an absorption wavelength in the ultraviolet region. The results show that the method is stable, accurate and reliable. And it is suitable for the preparation of PC sustained-release pellets.With roundness,friability, angle of repose and the yield of the target particle size being selected as main indexes. This article preparing potassium citrate pills contained core with two different methods: extrusion-spheronization and powder layering by centrifugal granulator. And investigated the factors of prescription and technological which effected the quality of pellets. Then an orthogonal design experiment was carried out to optimize these paramenters.Finally we have got pellets with roundness, friability qualified, high yield.This study fluidized bed coating technique was applied to prepare the sustained-release pellets. Hydroxypropyl methyl cellulose HPMC-E5 was used as coating material for gown and protective clothing. Surelease? was used as coating material for sustained-release clothing. Prepared act of the membrane potassium citrate sustained-release pellets.Investigated coating weight, the impact of a plasticizer, porogen, the aging time and other factors on release of sustained-release pellets. Also investigated the coating process parameters, such as: air supply frequency, the liquid velocity, temperature and coating atomization temperature. Determine the best coating formulation and coating process.Successfully made the potassium citrate sustained-release pellets. The study was based on Urocit?-k and Jieshitong? sustained-release tablets as a reference. f2 calculated as an indicator to compare four kinds of different media pH dissolution profile. The results show,f2> 50, self-made potassium citrate sustained-release pellets compared with the reference formulation the four media release were similar.The stability investigation shows that sustained-release pellets are stable at high temperature and light conditions. But it is more sensitive to humidity, moisture and therefore should prompt dark storage. Accelerated test showed that self-made potassium citrate sustained-release pellets have no significant change.By fitting the in vitro release model release mechanism has an understanding of the drug potassium citrate. The results showed that sustained-release pellets accords with first order release model.