Comparison Of Protective Effect On Gut Barrier Between Saponins Of Panax Notoginseng And Glutamine In Rats

Objective To compare the protective effect of saponins of panax notoginseng(PNS)with that of glutamine(Gln) on gut barrier in rats with intestinal ischemia-reperfusion (I/R) injury .Methods I/R injury rat model was established by occluding the superior mesenteric artery(SMA) for 1 hour and followed by reperfusion for 3 hours. Healthy S-D rats were randomly divided into 4 groups.Group A was I/R rats(n=10). Group B was rats by sham-operation(n= 10). Group C was rats who were treated with PNS 50mg/kg (3days ,q8h,n=20). Group D was rats who were treated with glutamine 1g/kg (3days ,q8h,n=20).Intestinal impairment was evaluated via mucosal histological changes under light and electron microscope and by measuring endotoxin concentration in...