The Research In The Relation Between SG P50 And Graded 6-OHDA Lesions In Substantia Nigra Pars Compacta

Objective To observe the sensory gating P50 and DA neurons in substantia nigra pars compacta(SNpc), and study the relation between them in SNpc with graded lesions. Methods 179 rats were divided into five groups(D7, D11, D17, D22 and D30)according to the days after lesion by 6-OHDA, and every group was further divided into four subgroups by their rotation behavior(0r/min, 1～3r/min, 4～6r/min and ≥7r/min). The SG P50, TH~+ cells in lesioned (right) SNpc and rotation behavior of the lesioned and the control rats were respectively tested in every course. Results 1 The rats exhibited different rotation behavior. 2 The changes of SG P50 and TH~+ cells were detected when the SNpc were mildly lesioned, and changed with the lesioned days and the rotation behavior. 3 The SG P50 were significantly correlated with the TH~+ cells in SNpc. Conclusions 1 The rotation behavior induced by APO is limited in weighting the TH~+ cells in SNpc. 2 The SG P50 reflects the TH~+ cells and the function well in SNpc when the SNpc are mildly lesioned. 3 The SG P50 is significantly correlated with the TH~+ cells in SNpc, and is a good index for the TH~+ cells in SNpc.