Expression Of Transgelin Gene In Myoma Of Uterus And Its Clinical Significance

ObjectiveUterus myoma is the most common benign tumor in female reproductive organs. It is present in 20～30% of reproductive-age women. It is 52% of benign tumor in female reproductive organs. The exact etiology and mechanism is unknown.Transgelin gene was found for the first time as a transformation and shape-change sensitive actin gelling protein in fibroblasts and smooth muscle. It was considered as the marker gene of VSMC. The results of some researches indicated that expression of transgelin gene is low in cancer of bladder, breast, kidney, colon and ovary, and is normal in their control groups. Transgelin's expression is very high in vascular smooth muscle tissue, and it located in cytoskele-ton. Therefore, we considered that Transgelin maybe related with genesis and progession of uterine myoma.To investigate the expression of Transgelin in uterine myoma tissue and to reveal its role in genesis and progression of uterine myoma, which will provide a theoretical basis for new conservative means to treat uterine myoma.MethodsThirty patients undergoing surgery for myoma of uterus and ten patients undergoing surgery for uterine prolapse at the shengjing Hospital of China Medical University from Aug to Dec 2005 were examined. Fresh samples of myoma tissue...