Absorption Kinetics Of HT And Development Of HT Sustained-release Capsule

The objective of this study was to develop HT sustained-release capsule which could steadily release drug in 12 hours in vivo, under the direction of biopharmaceutics and Pharmacokinetics.Absorption kinetics of HT was studied by the method of in situ rat intestinal perfusion before HT formulation developed because the preparation of oral formulation could be guided by absorption rate and kinetics. The result indicate that HT could absorb in the all rat intestinal and stomach. So it could be prepared to sustained-release formulation. The absorption of HT was bad, but all of absorption enhancers have some toxicity, so it was not considered to add. The liposolubilic adjuvant could be added to enhance absorption of HT.The UV method was established for the content determination of HT in the HT sustained-release capsule. The formulation and preparation technology was filtrated by the index of dissolution, diversity of content and granule fluidity. The various factors were studied which influence the HT release and the formulation was optimized by homogeneous design. The dissolution profile of 3 batchs of capsule indicate that the dissolution of HT sustained-release capsule had well reproducibility and homogenicity and accorded with demond of sustained-release formulation.The identification methods and the HPLC method for the content...