| Acute ischemic stroke is a devastating disease and a major health problem worldwide, it is one of the highest mortality diseases and it can also cause long-lasting disability in adults. In North America, the 650000 patients that suffer a stroke each year represent a substantial human and financial cost to society. In the past several years, our understanding of the molecular mechanisms underlying stroke injury has greatly increased. Cerebral ischemia may lead to irreversible neuronal damage at the core of the ischemic focus. Neuronal dysfunction may be reversible in the surrounding area, the penumbra. Ischemic tissue damage is multifactorial and involves excitotoxicity, reactive oxygen species (ROS), inflammation, and apoptosis.Radix Angelica Sinensis(AS), sometimes referred to by its Chinese name as Danggui, is the root of Angelica sinensis (Oliv.) Diels, a herbaceous perennial plant belonging to the Umbellfrae Family. ASD has been known for a long time for its effects of tonifying blood and increasing circulation and utilized as a valuable remedy for anemia, menstrual irregularities, and constipation in traditional Chinese medicine. More than 70 formulae collected in the Chinese pharmacopoeia (2000) contain AS as one of the main ingredients. Moreover, ASD has been used as a health food and one of the ingredients in cosmetics. Previous investigations suggest that the main bioactive ingredients of ASD are polysaccharides, flavonoids, phthalides, coumarins, flavonoids and ferulaic acid, etc. It was also reported recently that angelica lactone is a bioactive compound to in improve blood fluidity and inhibit platelet aggregation, which can utilize as a valuable remedy for all kinds of ischemia. However, it is not known whether angelica lactone has any direct neuroprotective...
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