| Objective: To ascertain the pharmacological effect of traditional Chinese medical compound naozhongxiao that can intervene the cerebral edema in rats with focal cerebral ischemia. And to probe and analyse the action mechanism of naozhongxiao in many ways in cerebral edema at the acute ischemic apoplexy stage. The results of the study provided an experimental basis for developing the clinical application of naozhongxiao. Methods and Contents: It had been erected that the model of focal cerebral ischemia with suture-occluded method in rats in order to observe the effects of naozhongxiao on the content of cerebral water, Na+, K+, Ca2+, nitric oxide (NO) and the activity of Na+-K+-ATPase, Ca2+-ATPase. Results: Both naozhongxiao and weinaolutong could decrease to some degree the content of cerebral water, Na+, Ca2+ ,NO (P<0.05) and increase the conten of K+, the activity of Na+-K+-ATPase, Ca2+-ATPase (P<0.05). Compared with model group, the high dose group of naozhongxiao showed most significant effect. Conclusion: Naozhongxiao showed markedly preventive effect on cerebral edema in focal cerebral ischemia rats. The mechanism could be concerned with relieving the energy dysmetabolism, acommodating the ionic balance of exterior and interior of cell and decreasing the NO level in brain. The other pharmacological mechanisms of naozhongxiao have yet to be Investigated.
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