Quantitative Study Of Lumbar Vetebrate Bone Mineral Density And Coronary Artery Calcification In Aged Population

Objective To analyze the result of lumbar vetebrate bone mineral density and coronary artery calcification, and investigate the correlation between osteoporosis and coronary atherosclerosis in the old patients and their probable mechanism. Methods 64 patients underwent quantitative CT ( QCT ) of lumbar vertebrae for bone mineral density(BMD) and muliti-slice spiral CT (MSCT) of coronary artery for calcification score and totals calcification score(TCS), filled out interview sheet for the details of general condition, lifestyle and other factors. All patients were divided into osteoporosis group and non-osteoporosis group, the result of clinical data and TCS were compared between two groups. In addition, Patients were divided into two groups according to the TCS: group A(TCS>50), group B(TCS≤50).The clinical data and BMD were compared between two groups. Analysis of osteoporosis and factors was done by using multiple regression . Result TCS were significantly higher in group of osteoporosis than in group of non-osteoporosis (P<0.05) .Additional, the age, BMD of lumbar spine ,Ca, TC, TG, HDL were significantly different between the group of TCS > 50 and the group of TCS≤50 (P<0.05) ;while there was no significant difference in BMI\ LDL, phosphorus,apoA, apoB (P>0.05) . Multiple regression analysis showed that the factors for TCS in patients included age, smoking,high density lipoprotein(HDL) and BMD, while age, smoking and TC were risk factors, TCS was increased by reducing of HDL or BMD.There was negative correlation between the coronary artery calcification score and BMD. Conclusions This study suggesting that patients of osteoporosis tend to have a higher risk of developing coronary calcification. Osteoporosis was correlated with coronary atherosclerosis ,...