The Clinical Study Of Perioperative Fluid Therapy For Liver Transplantation

Objective: To investigate the correlation between intraoperative and postoperative fluid therapy and postoperative early complication, then according to the investigation, to provide the reasonable fluid therapy measure for the perioperative period.Method: The clinical data of 62 patients receiving liver transplantation in our hospital from July 1996 to December 2005 were retrospectively analyzed. Based on early phase prognosis after liver transplantation, the 62 patients were divided into the complication group and the none-complication group (complication included lung oedema, acute lung injury, ARDS, abdominal cave infection, lung infection, MODS and death).Twenty-four variables were analyzed in both groups of pre-operation, intra-operation, and the first 3 days of post-operation to screen out several variables affecting the early prognosis.Result: The complication group included 29 patients (46.77%) and 3(4.84%) of them died during the perioperative period. Using monofactorial analysis for each variable, there were significances between the two groups in the following variables: preoperative lung function, intraoperative transfusion requirements, intraoperative bleeding volume, intraoperative difference between in and out of fluid volume, transfusion requirements for the first day after operation and fluid balance(≤-500ml) in≥2 days of the first 3 days of post-operation. Analysis of the relationship between multivariate risk factors and prognosis after liver transplantation by logistic regression analysis showed that preoperative lung function, intraoperative bleeding volume, transfusion requirements for the first day after operation and fluid balance(≤-500ml) in≥2 days of the first 3 days of post-operation were risk factors.