A Study On The Relationship Between Vascular Endothelial Growth Factor Serum Level And Virus Hepatitis

Objective: To investigate the serum level of vascular endothelial growth factor (VEGF) in virus hepatitis patients and the relationship between VEGF and hepatic function index, regeneration as well as prognosis.Methods: The serum level of VEGF in 120 patients with virus hepatitis and 12 healthy individual (control group) was detected by ELISA technology.Results:(1) The serum level of VEGF of 120 patients with virus hepatitis was higher than of the healthy individual (P=0.000), the serum level of VEGF of the liver cirrhosis group was lower than of healthy individual (P=0.025). There was no statistical difference between the serum level of VEGF of patients with chronic virus hepatitis and of healthy individual (P=0.279). The serum level of VEGF of acute virus hepatitis or of severe hepatitis patients was significantly increased comparing with healthy individual (P=0.000). (2) The serum level of VEGF was positive correlation with AFP, (rs=0.914,P=0.000), and have no relationship with the serum level of alanine,aminotransferase, aspartate aminotransferase, total protein and albumin. (3) There was difference in serum level of VEGF among the severe hepatitis patients: Serum VEGF level in survival group was more elevated than in healthy individual (P=0.000), Serum VEGF level in die group was slightly elevated than in healthy individual but there was not statistical significance (P=0.202). At convalescence, the Serum VEGF levels in the survivor of severe hepatitis patients were significance more elevated than initial stages. The Serum VEGF levels in the fatal hepatitis gravis patients show a decrease tendency in extrimis.