The Cytokines Level And The Discrepancy Of Intervening Of Dexamethasone In ALI Rats Induced By Different Factors

Objective: Acute lung injury (ALI), a syndrome of pulmonary inflammation characterized by alveolar-capillary increased permeability, is a serious complication in the patients with critical illnesses, resulted from a variety of clinical reasons such as severe pneumonia, shock, multiple trauma and aspiration of gastric contents. ALI often leads to acute respiratory distress syndrome (ARDS). All the clinical reasons can be divided into two cases: a direct insult on lung cells (pulmonary ARDS (ARDSp) such as severe pneumonia, aspiration of gastric contents) or indirectly (extrapulmonary ARDS (ARDSexp) such as shock, serious sepsis).ARDS is characterized by an acute inflammatory response in the lung parenchyma that is associated with severe injury to the endothelial and epithelial barriers. ARDS involves an intense inflammatory response in the lung, with accumulation of both pro- and anti- inflammatory cytokines in BALF and blood. Despite improvement in supportive care and multiple therapeutic efforts directed at modifying the course of this condition, mortality still remain about 50%. Prompt and significant solutions are required.