Temporal Profile Of Matrix Metalloproteinase And Tissue Inhibitor Of Metalloproteinase After Spontaneous Intracerebral Hemorrhage And Relationship To Clinical Outcome

Purpose: cerebral stroke is the third reason of human death and a common and constant disease in neurology department. Intracerebral hemorrhage (ICH) refers to primary cerebral intracephalic bleeding, representing 10%~30% of all strokes. ICH is the common disease in the bad way that occurs frequently at clinical Neurology, which access unexpectedly, make progress rapidly and high mortality (40%~60%) and morbidity, no effective treatment has been develop. Cerebral edema, together with ICH enlargement, has been shown to be responsible for poor outcome in some patients. Therefore, a better understanding of molecular changes underlying these complications is required and may contribute to become a new approach in the treatment of ICH. matrix metalloproteinases(MMPs)are a family of neural proteases, which degrade extracellular matrix. MMP-9 ,which is also called gelatinase B, play an important part in degrading the cerebrovascular basal lamina. Tissue inhibitors of metalloproteinase (TIMPs) are endogenous inhibitors that regulate the activity of the MMPs. The disturbance of the equilibration between MMPs and TIMPs is associated with the secondary brain injury after acute...