Effects Of Deoxynivalenol On Apoptosis Of Human Gastric Carcinoma Cell Line SGC-7901,BGC-823 Cells In Vitro

Objective: The treatment of malignant tumors has been one of the main fields of medical research. As the development of science and technology, dramatic progress in the treatment of tumors has been achieved in the past decades. Now, the therapeutic methods of tumor are far beyond they used to be and some toxic substances have already been used in clinical treatment of tumors successfully. Arsenic trioxide is the best typical example. Deoxynivalenol (DON, vomitoxin) is a trichothecene secondary metabolite produced by Fusarium species. Previous studies indicated that DON has potent toxicity to many kinds of cells, such as procaryotic cells, eucarhotic cells and tumor cells. It could inhibit the synthesis of biomacromolecule and protein. But there is no uniform conclusion about the carcinogenicity and mutagenicity of DON. Now, the research about DON is focus on the way of detection, immunotoxicology and the effects of DON on normal cells, while little study about the effects of DON on tumor cells. To explore the possible effects of DON on the tumor cells and support the theory for the clinical...