Experimental Studies About The Effects Of Vitamin C On Immunological Inhibition Induced By Deoxynivalenol In Vitro

Objective : Trichothecene mycotoxin is a group of structurally similar fungal secondary metabolites including some of the most potent inhibitors of protein synthesis known, and that has been implicated in both animal and human toxicoses. Deoxynivalenol (DON, vomitoxin) is the deoxyderivative of nivalenol, and is produced by various species of the fungal genus Fusarium. Excessive rainfall and cold weather as well as improper storage conditions can lead to Fusarium colonization and elaboration of VT, so DON contamination of grain is a very common phenomenon in the world. As we have known, DON is one of the predominant contaminating mycotoxins in the grain and foodstuffs of the areas with high incidence of esophageal cancer in China. Previous studies showed that dietary VT had chronic effects on experimental animals including reduced body weight gain, feed refusal and vomiting and VT ingestion experimentally impairs host resistance, humoral immunity and cell-mediated immune function.Epidemiological studies have demonstrated that the...