Empirical Study Of The Effects Of Allicin On TNF-α In ALI Mice

Objective: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are devastating illness in clinic patients. The mortality of ALI/ARDS was high incidence, which was repoted to be 40%～60%. Ashbaugh et al first described ARDS in 12 patients in 1967. In 1994, the American-European Consensus Conference Committee proposed the currently used definition of ARDS and thought that ALI/ARDS refered to acute progressive respiratory failure with stubborn hypoxemia induced by different predisposing factors except cardiogenic causes, which was a major component of systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). ARDS is the severe endpoint of ALI. Multiple inflammatory mediators release without being controlled have been considered to contribute to the genesis of ALI/ARDS. Keiss et al, Drug research center of Munich university in Germany, reported that the abstract of Allium satirum.L could inhibite nuclear factor kappa B (NF-κB) activation induced by lipopolysaccharide (LPS) in human blood cells, and could decrease the production of the pro-inflammatory cytokines, example of tumour necrosis factor-α(TNF-α) and interleukin-1β(IL-1β). The thesis reported that allicin could...