Investigation Of T-2 Toxin In Wheat And Corn And Risk Assessment Of Dietary Intake In Six Provinces In China

T-2 toxin is mycotoxin of the group trichothecenes type-A produced by fungi of the Fusarium genus, i.e. Fusarium sporotrichioides, F. tricinctum, F.poae, and F. acuminatum, which is one of the most toxic in type-A trichothecene mycotoxin. The main toxicity effects of T-2 toxin on animals are about Haematology and immunology. T-2 toxin could inhibit synthesis of DNA and RNA and cause apoptosis of cells. In male mice, T-2 toxin could cause hepatocellular and pulmonary adenomas. No data were available on the carcinogenicity to humans. If people eating grains contaminated by high-dose T-2 toxin mistakely, the main pathological changes were pronounced leucopenia, necrotic lesions of the oral cavity, oesophagus, and stomach, bonemarrow hypoplasia and aplasia besides vomiting, abodominal pain and diarrhoea. Alimentary toxic aleukia(ATA) was lethal in a high proportion of cases. T-2 toxin is commonly found in various cereal crops such as wheat, maize, oats, barley and beans. The grains that wheat, maize and oat can be contaminated by T-2 toxin most easily. The Fusarium fungi are commonly found on cereals grown in the temperate regions of America, Europe and Asia. Surveys have revealed the presence of T-2 toxin in wheat and maize in regions that KBD and wheat and rice in no KBD in CHINA.The Joint FAO/WHO Expert Committee on Food Additives (JECFA) and EU member states and many countries have summarized the nature of the toxicological of T-2 toxin thoroughly, and studied contamination n deeply. JECFA and Nordic Working Group provided the maximum tolerate level(tolerable daily intake, TDI ).